Pharmacology: SSRIs

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Introduction:

Selective serotonin reuptake inhibitors (SSRIs) have revolutionized the treatment of depression and various other psychiatric disorders since their introduction in the 1980s. SSRIs primarily act by increasing the levels of serotonin, a neurotransmitter implicated in mood regulation, within the brain's synaptic spaces. Let's delve into the pharmacodynamics of SSRIs and explore how these medications work.

Mechanism of Action: An Overview

The primary mechanism of action of SSRIs involves the inhibition of serotonin reuptake, which is why they are named Selective Serotonin Reuptake Inhibitors. By inhibiting the reuptake of serotonin, these drugs increase the serotonin concentration within the synapse, which enhances and prolongs the neurotransmitter's effects.

Serotonin Transporter Proteins: The Primary Target of SSRIs

Serotonin transporter proteins (SERT) are the principal target of SSRIs. These proteins facilitate the reabsorption of serotonin back into the neuron, reducing its availability in the synapse. SSRIs bind to these transporter proteins and inhibit their function, thereby increasing the amount of serotonin in the synaptic cleft. This boost of serotonin contributes to improved mood and reduced anxiety in individuals taking these medications.

Individual SSRIs: Subtle Differences Matter