Serotonin Discontinuation Syndrome

Managing Unwanted Side Effects

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Understanding Serotonin Discontinuation Syndrome

With some medications there are risks associated with abrupt discontinuation. This is true for anti-epileptic medication, lithium, benzodiazepines, and others. It is also true for some antidepressants. When antidepressant discontinuation induces w/d symptoms it is referred to as Serotonin Discontinuation Syndrome (SDS). The purpose of this post will be to discuss what SDS is, which antidepressants are most frequently associated with this condition, as well as tips for prevention and symptom management.

What is Serotonin Discontinuation Syndrome?

Serotonin Discontinuation Syndrome, often mislabeled as 'serotonin withdrawal syndrome,' is a constellation of symptoms that might occur after discontinuing or reducing the dosage of antidepressant medications that modulate the